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Revista latinoamericana de química
versão impressa ISSN 0370-5943
Resumo
LANDEIRA, Lucía et al. Synthesis and anthelmintic evaluation of [2,5']-bis-heterocycles as bengazole analogs. Rev. latinoam. quím [online]. 2013, vol.41, n.1, pp.38-49. ISSN 0370-5943.
As part of our search for compounds as candidates for anticancer or antiparasitic drugs employing molecular simplification, we reported the preparation of uncommon [2,5'] bis-heterocycles employing efficient synthetic strategies. The synthesized compounds presents little modifications of the Bengazole heterocyclic fragment in order to preserve the biological properties to been employed in Bengazole derivatives analogs preparation. A limitation in the oxidation of 2-benzyl-oxazolines is described. We also presents the anthelmintic activities of these synthetized compounds.
Palavras-chave : Bengazole; [2,5']bithiazole; [2,5']bis-heterocycle; Hantzsch; anthelmintic activity.