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Gaceta médica de México
versão On-line ISSN 2696-1288versão impressa ISSN 0016-3813
Resumo
TRUJILLO-ESTEVES, Celina; MAYORAL-FLORES, Nadia Helena; SOTO-RIVERA, Bernardo e ROSAS-BARRIENTOS, José Vicente. Analgesia preventiva con pregabalina en pacientes postoperados de colecistectomía laparoscópica. Gac. Méd. Méx [online]. 2019, vol.155, suppl.1, pp.22-26. Epub 01-Jul-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.19005136.
Background:
Preventive analgesia is the administration of an analgesic drug with the aim of attenuating post-operative pain, hyperalgesia and allodynia. Its use is justified in order to offer analgesia and reduce anxiety in patients undergoing laparoscopic procedures.
Objective:
To evaluate if pregabalin in a dose of 1 mg/kg of weight is effective as preventive analgesia in post-operated laparoscopic cholecystectomy patients.
Methods:
A single-blind controlled clinical trial was conducted, which included 60 patients scheduled for laparoscopic cholecystectomy randomly divided into 2 groups, where Group 1 received placebo and Group 2 received pregabalin a daily dose 72 h prior to surgical intervention. The intensity of pain was assessed using the emergency nurses association scale at 2, 6, 12 and 24 post-operative h, as well as the level of presurgical anxiety with the Hamilton scale.
Results:
Pain reduction was demonstrated in patients in the pregabalin group from the 1st h (p = 0.002), later the decrease in pain was more noticeable compared to patients who were given placebo (p < 0.001), the same happened with the anxiety level evaluated with the Hamilton scale (p < 0.005).
Conclusion:
The use of pregabalin as preventive analgesia turns out to be effective in the post-operative period and the pre-operative anxiety with minimal adverse effects in the post-operated patients of laparoscopic cholecystectomy.
Palavras-chave : Preventive analgesia; Postoperative pain; Pregabalin; Laparoscopic cholecystectomy.