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Gaceta médica de México
versão On-line ISSN 2696-1288versão impressa ISSN 0016-3813
Resumo
PARRA-ORTEGA, Israel et al. Natural killer cell reconstitution after hematopoietic stem-cell transplantation in children. Gac. Méd. Méx [online]. 2020, vol.156, n.3, pp.188-194. Epub 27-Maio-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.20005384.
Introduction:
After hematopoietic stem cell transplantation (HSCT), natural killer (NK) cells reconstitution is the main barrier against viral infections. Objective: To determine that the knowledge on the kinetics of NK cell reconstitution after HSCT contributes to transplant efficient monitoring, which increases the possibility of its success.
Method:
Twenty-one patients undergoing HSCT were included, as well as a control group of clinically healthy individuals. At different time points after transplantation (range of 21 to 670 days), CD3- CD16+ CD56+ NK cells were quantified by flow cytometry in peripheral blood samples.
Results:
NK cell recovery occurs at three to six months and 10 to 12 months post-transplantation; their number was significantly lower (in comparison with the control group) in the rest of the monitoring time.
Conclusions:
The first period of NK cell recovery occurs between three and six months after transplantation. Reconstitution is transient and the number of NK cells varies in the first years.
Palavras-chave : Natural killer cells; Transplantation; Hematopoietic cells; Cell reconstitution.