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Revista de investigación clínica
versão On-line ISSN 2564-8896versão impressa ISSN 0034-8376
Resumo
MARTINEZ-EZQUERRO, José D. et al. Oxidative Stress, Telomere Length, and Frailty in an Old Age Population. Rev. invest. clín. [online]. 2019, vol.71, n.6, pp.393-401. Epub 09-Abr-2021. ISSN 2564-8896. https://doi.org/10.24875/ric.19003116.
Background
A global aging population requires focusing on the risk factors for unhealthy aging, preventive medicine, and chronic disease management. The identification of adverse health outcomes in older adults has been addressed by the characterization of frailty as a biological syndrome. In this field, oxidative stress and telomere length have been suggested as biomarkers of aging
Objective
The objective of the study was to study the association of oxidative stress, telomere length, and frailty in an old age population
Methods
We conducted a cross-sectional study based on 2015 data from 202 members of a cohort of older adults (n = 202; F/M gender ratio: 133/69; mean age: 69.89 ± 7.39 years). Reactive oxygen species were measured by dichlorofluorescein diacetate and lipid peroxidation by malondialdehyde. Telomere length was determined using quantitative polymerase chain reaction with SYBR Green Master Mix
Results
Statistical analysis showed an association between telomere length and frailty but no association between oxidative stress and telomere length or frailty
Conclusions
Telomere length could eventually be used as a marker to differentiate between healthy and unhealthy aging as expressed by frailty phenotype; oxidative stress seemed merely a biological process of aging.
Palavras-chave : Healthy aging; Biomarkers; Homeostasis; Frailty.