Resumo

CHICO PONCE DE LEON, Fernando. Craniosynostosis. I. Biological basis and analysis of nonsyndromic craniosynostosis. Bol. Med. Hosp. Infant. Mex. [online]. 2011, vol.68, n.5, pp.333-348. ISSN 1665-1146.

Craniosynostoses are defined as closure, ossification and sclerosis of one or more cranial sutures. This condition causes different grades of brain compression, intracranial hypertension and detriment of intellectual coefficient and vision. In the first part of this review article, an overview of the history of craniosynostosis is presented from prehistorical times through the subsequent centuries, culminating with the French and Mexican experience. The Hospital Infantil de México Federico Gómez series are also presented. Following this, the biological bases are summarized including embryogenetic, epidemiological and etiological features, as well as pathophysiological, clinical and imaging aspects. Finally, seven different types of nonsyndromatic craniosynostoses are analyzed including those with one or more sutures.

Palavras-chave : craniosynostosis; nonsyndromic; biological basis; clinical features.

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