Resumo

CALDERON-MOORE, Antonio; PIZARRO-CASTELLANOS, Mariel  e  RIZZOLI-CORDOBA, Antonio. Systematic review of the efficacy and safety of omega 3 and omega 6 fatty acid supplementation in developmental neurological disorders. Bol. Med. Hosp. Infant. Mex. [online]. 2012, vol.69, n.4, pp.265-270. ISSN 1665-1146.

Background. Available information on clinical guidelines and review articles is controversial and is insufficient to determine the clinical efficacy of supplementation with omega 3 and omega 6 fatty acids in neurodevelopmental disorders. Additional treatment may be effective for the treatment of these disorders. Methods. We conducted a systematic review based on the guidelines of the Cochrane group by searching for clinical trials in MEDLINE, COCHRANE DATA-BASE in the time interval 1990 to 2011, in English and Spanish, and in pediatric patients that comply with the information required by the CONSORT group. One hundred and two articles were obtained; 97 articles were excluded choosing five randomized, double-blind, placebo-controlled trials to perform the review. Results. In the trials analyzed we found no significant difference in the improvement of ADHD symptoms between placebo group and the intervention, but there was clear clinical improvement. No serious adverse events were reported. There are no similar characteristics in the reviewed articles to carry out a meta-analysis and accurate assessment of the effectiveness of supplementation. Conclusions. With the results of this systematic review, we cannot state categorically that the use of this supplementation is significantly effective due to the different characteristics of the studies described above. However, due to clinical improvement and adequate safety profile, it may be useful without replacing pharmacological treatment.

Palavras-chave : essential fatty acids; omega 3; omega 6; attention deficit disorder.