Resumo

ESQUIVEL-FERRINO, Patricia C. et al. Volatile Constituents Identified in Hexane Extract of Citrus sinensis Peel and Anti-Mycobacterial Tuberculosis Activity of Some of its Constituents. J. Mex. Chem. Soc [online]. 2014, vol.58, n.4, pp.431-434. ISSN 1870-249X.

Tuberculosis (TB) is a great cause of morbidity and mortality around the world. The increasing incidence of multidrug-resistant (MDR) Mycobacterium tuberculosis and co-infection TB-AIDS led to the need to develop new TB drugs, and plants could be a source of them. The hexane extract of Citrus sinensis with anti-TB activity was analyzed by GC-MS. This analysis showed the presence of 40 volatile components, including monoterpenes (81.74%), sesquiterpenes (1.32%), fatty acids (1.15%), and some other oxygenated non-aromatic compounds (15.73%). Some identified compounds were tested against M. tuberculosis H37Rv, and one clinical isolated MDR M. tuberculosis strain. Results showed that palmitic acid, decanal, caryophyllene oxide, and cis-limonene oxide contributed to the anti-TB activity of hexane extract of C. sinensis peel.

Palavras-chave : Citrus sinensis; GC-MS; Mycobacterium tuberculosis; anti-TB compounds.