Resumo

BARROS-CASTILLO, J.C.; CALDERON-SANTOYO, M.; RIVERA-AGUILAR, J.O.  e  RAGAZZO-SANCHEZ, J.A.. High-value biological compounds in jackfruit (Artocarpus heterophyllus Lam.): Postulates of their anticancer possible mechanisms. Revista bio ciencias [online]. 2023, vol.10, e1403.  Epub 22-Fev-2023. ISSN 2007-3380.  https://doi.org/10.15741/revbio.10.e1403.

Jackfruit contains high-value biological compounds with important biological activity in the inhibition of carcinogenesis. This study aimed to identify the metabolites in a methanolic fraction of an extract of jackfruit; which was reported with antimutagenic and antiproliferative activity but not characterized. Identification of compounds and reports of their documented anticancer activity permitted the establishment of postulates about their possible inhibition mechanisms of the carcinogenesis process. The profile includes 21 compounds, among them apigenin, artocarpin, cudraflavone C, moracin C, and β-carotene are the metabolites with important biological activity against cancer cells in the different phases of carcinogenesis.

Palavras-chave : Jackfruit; anticancer metabolites; biological activity; carcinogenesis process; apoptosis.